HeHCC

We aim to perform an in-depth analysis of intra-tumor heterogeneity in hepatocellular carcinomas (HCC) to unravel how the interplay between genomic alterations in tumor cells and the tumor microenvironment leads to the growth of heterogeneous tumors. To this aim, we have collected a series of 20 HCC with macroscopic heterogeneity for which several tumor samples (2-4) have been sampled in different tumor locations, and 5 cases with primary tumor and relapse. Matched paraffin blocks of all samples have been reviewed by specialized liver pathologists and are available for immunohistological studies.

Publications :

• Bayard Q et al. Cyclin A2/E1 activation defines a hepatocellular carcinoma subclass with a rearrangement signature of replication stress. Nature Communications 2018, vol. 9 issue 1
• Meunier L et al. DNA Methylation Signatures Reveal the Diversity of Processes Remodeling Hepatocellular Carcinoma Methylomes Hepatology 2021, vol. 74, issue 2