We aim to test the hypothesis according to which specific associations between microbiome and genome diversities could form a combined molecular basis of obesity. To test this hypothesis we propose to exome-sequence 400 severely obese (BMI>35kg/m2) patients and 100 lean controls benefiting from an existing project (EU-MetaCardis) in which 80% of participants have their gut metagenomes currently in sequencing.
Our consortium (ICAN, CNG, MGP) has the right set of expertise (clinical, genome, metagenome, data analysis and integration) to conduct this project C-METAGENOB.
